Blow-Fill-Seal
Form, fill and seal in one sterile step
Blow-fill-seal technology moulds the container, fills it and seals it inside a closed process, cutting handling steps and contamination risk for eye drops, respiratory solutions and more.
We can help you evaluate whether BFS suits your products.
Blow-fill-seal
Containers are formed, filled and sealed in one closed cycle without human contact.
Step 1 of 3: Forming
A molten plastic tube is clamped in the mould and blown or vacuum-formed into a container.
Step 2 of 3: Filling
Sterile-filtered solution is dosed into the new container through a filling mandrel.
Step 3 of 3: Sealing
Head moulds close to form the top and seal the container, which is then released.
A full blow-fill-seal line from water and solution preparation to inspected, labelled packs.
Step 1 of 8: Water treatment
Feed water is purified and distilled into water for injection.
Step 2 of 8: Solution preparation
The drug solution is mixed, filtered and held ready for filling.
Step 3 of 8: Blow-fill-seal
Plastic containers are formed, filled and sealed in one continuous aseptic step.
Step 4 of 8: Capping
Caps are added to the sealed containers where the product requires them.
Step 5 of 8: Autoclaving
Filled containers are terminally sterilised with steam where the product allows it.
Step 6 of 8: Inspection
Containers are checked for leaks, particles and forming defects.
Step 7 of 8: Labelling
Labels are applied to each container.
Step 8 of 8: Packing & distribution
Containers are cartoned, palletised and stored for dispatch.
Where it is used
- Eye drops
- Respiratory solutions
- Single-dose units
- Large-volume parenterals
Tell us what you need
We source equipment for blow-fill-seal project by project through our network of international manufacturers. Share your product, capacity and timeline and we will come back with options.
Related segments
Planning a new line?
Tell us about your product, capacity and timeline. Our team will come back with options from the manufacturers we work with.
Sagueny Group Seminar
Manufacturers and industry experts under one roof: production lines, meat and poultry processing, packaging and quality control.
See the event